On a tank trailer specifically, what can happen if the drive wheels or the trailer wheels begin to skid?

49 CFR §383.119(i) – General operating practices and procedures for tank vehicles not otherwise specified; AAMVA CDL Manual §8.3.5.

Jackknifing is one of the most dangerous loss-of-control events a combination vehicle can experience, and the manual flags tank trailers as particularly vulnerable to it once a skid starts. Knowing this risk helps explain why smooth inputs and prompt corrective action are emphasized throughout the tanker section.